String of bombings kill 101, injure 200 in Pakistan


QUETTA, Pakistan (Reuters) - At least 101 people were killed in bombings in two Pakistani cities on Thursday in one of the country's bloodiest days in recent years, officials said, with most casualties caused by sectarian attacks in Quetta.


The bombings underscored the myriad threats Pakistani security forces face from homegrown Sunni extremist groups, the Taliban insurgency in the northwest and the less well-known Baloch insurgency in the southwest.


On Thursday evening, two coordinated explosions killed at least 69 people and injured more than 100 in Quetta, the provincial capital of Balochistan, said Deputy Inspector of Police Hamid Shakil.


The first attack, in a crowded snooker hall, was a suicide bombing, local residents said. About ten minutes later, a car bomb exploded, they said. Five policemen and a cameraman were among the dead from that blast.


The attacks happened in a predominately Shia neighborhood and banned sectarian group Lashkar-e-Jhangvi claimed responsibility. The extremist Sunni group targets Shias, who make up about 20 percent of Pakistani's population.


Targeted killings and bombings of Shia communities are common in Pakistan, and rights groups say hundreds of Shia were killed last year. Militant groups in Balochistan frequently bomb or shoot Shia passengers on buses travelling to neighboring Iran.


The killers are rarely caught and some Shia activists say militants work alongside elements of Pakistan's security forces, who see them as a potential bulwark against neighboring India.


Many Pakistanis fear their nation could become the site of a regional power struggle between Saudi Arabia, source of funding for Sunni extremist groups, and Iran, which is largely Shia.


But sectarian tensions are not the only source of violence.


The United Baloch Army claimed responsibility for a blast in Quetta's market earlier in the day. It killed 11 people and injured more than 40, mostly vegetable sellers and secondhand clothes dealers, police officer Zubair Mehmood said. A child was also killed.


The group is one of several fighting for independence for Balochistan, an arid, impoverished region with substantial gas, copper and gold reserves, which constitutes just under half of Pakistan's territory and is home to about 8 million of the country's population of 180 million.


SWAT BOMBING


In another incident Thursday, 21 were killed and more than 60 injured in a bombing when people gathered to hear a religious leader speak in Mingora, the largest city in the northwestern province of Swat, police and officials at the Saidu Sharif hospital said.


"The death toll may rise as some of the injured are in critical condition and we are receiving more and more injured people," said Dr. Niaz Mohammad.


It has been more than two years since a militant attack has claimed that many lives in Swat.


The mountainous region, formerly a tourist destination, has been administered by the Pakistani army since their 2009 offensive drove out Taliban militants who had taken control.


But Talibans retain the ability to attack in Swat and shot schoolgirl campaigner Malala Yousufzai in Mingora last October.


A Taliban spokesman said they were not responsible for Thursday's bombing.


(Additional reporting by Jibran Ahmad in Peshawar, Pakistan; Writing by Katharine Houreld; Editing by Mark Heinrich and Jason Webb)



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Warnings handed to China celebrities over censorship row






BEIJING: Chinese authorities handed warnings to several celebrities who voiced support for a newspaper at the centre of a censorship battle online, newspaper reports and social media posts said on Friday.

Taiwanese singer Annie Yi, who works in mainland China, said on her social media account that she had been invited to "drink tea" with authorities, a common euphemism for being cautioned by authorities, the South China Morning Post reported.

The warning came after Yi -- who has more than six million followers on Sina Weibo, a Chinese website similar to Twitter -- expressed support for Southern Weekly, a newspaper at the centre of protests over government censorship this week.

Other Chinese celebrities, including the former head of Google China, Kai-Fu Lee, and property tycoon Ren Zhiqiang also said they received invitations to "drink tea", after posting messages in support of the paper, according to online posts.

The two men have a combined 38 million followers on the site, which had more than 400 million registered users in 2012.

Chinese activists have previously said that invitations to "drink tea" are extended by state security police, who use such meetings as warnings not to engage in anti-government activities.

Several Chinese celebrities posted messages in support of the Southern Weekly this week, after journalists at the paper protested government censors' replacement of a pro-reform editorial.

Yao Chen, an actress who has 32 million followers on her Weibo account, earlier posted the paper's logo and quoted Russian dissident Alexandr Solzhenitsyn: "One word of truth shall outweigh the whole world".

Southern Weekly was published as scheduled on Thursday, after reports that newspaper staff had struck a deal with authorities that the paper would not be censored before publication.

- AFP/al



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BJP's Hindutva forces back in limelight

LUCKNOW: It was in late 1990, after the then chief minister Mulayam Singh Yadav ordered firing on unarmed Kar Sevaks leaving several dead and subsequently leading to Hindu outrage across the state that Kalyan Singh came up as a prominent discovery on Hindutva front. It was Bharatiya Janata Party's pan-Hindu outreach initiative which led Singh, belonging to the backward caste of Lodhs, ride the crest of Hindutva wave.

After being in and out of the party twice in the past, Kalyan already planning to make a third time entry in BJP, might put the party's shunned ideology at centre stage.

After remaining as chief minister in the BJP government twice -- 1991-1992 and 1997-1999, Kalyan left the party for the first time in December 1999 and returned again in January, 2004 before the Lok Sabha elections. He contested the 2004 Lok Sabha elections on the BJP ticket from Bulandshahar. Again before the Lok Sabha election of 2009, he left BJP and contested election from Etah Lok Sabha seat as an independent and subsequently won it.

Cut to 2012:

BJP's poor performance and Kalyan Singh' failure to present his own creation -- Jan Kranti Party, as a force to reckon with in 2012 Assembly election brought both of them closer, while Samajwadi Party-led by Mulayam's son Akhilesh Yadav won the election with majority.

Though third rejoining likely in over a decade, Kalyan's re-entry in BJP, now expected anytime, political pundits feel could be an attempt to repeat 1991 and 1998 history partially if not in totality. But, what can be for sure said is that the saffron outfit is on way to make yet another bid to revive hindutva, feel political experts.

The effort gains prominence with subsequent developments which have taken place in the state BJP in the past a few months.

The indicators:

Giving credence to the strategy is the debut made by firebrand sanyasin Uma Bharti in UP politics winning Charkhari assembly seat, rare presence of torch-bearers of hindutva Gorakhpur MP Yogi Adityanath and Pilibhit MP Varun Gandhi at party's state council meeting and unanimous election of Laxmikant Bajpayi, a known hardliner, as state BJP chief.

Former chief minister of Madhya Pradesh Uma Bharti, who is known for her firebrand image, rejoined BJP after a hiatus of a few years, has made a comeback in mainstream politics, for the first time from Uttar Pradesh's Charkhari. She won the seat in UP assembly election this year.

Besides, torch-bearers of hindutva including Pilibhit MP Varun Gandhi and Gorakhpur MP Yogi Adityanath were among a few, who have also hogged the limelight at the party's state council meeting held at erstwhile Capitol picture hall on December 2.

While the Rashtriya Swayemsewak Sangh (RSS)-backed Gorakhpur MP Yogi Adityanath is said to have made one of his first visit at the BJP's state council meeting. Yogi while talking to TOI had admitted that it was his first visit to the state BJP office. About his presence, the firebrand MP and torch-bearer of Hindutva said that even after his busy schedule in Gorakhpur, he had come to express support to newly-elected state BJP chief Laxmikant Bajpayi.

Both Yogi and Gandhi had remained out of sight for different reasons during UP Assembly elections in March 2012 clearly indicating differences among senior party leaders.

Last but not the least, the unanimous election of Laxmikant Bajpayi, known for his hardliner image, for full three-year term as state BJP chief.

With past political experiences proving that any communal simmering in the state has benefitted both 'Mullah' Mulayam's (called by Sadhvi Ritambhara after 1990 firing on kar sevaks) Samajwadi Party and Bharatiya Janata Party on politics of polarisation, around a dozen communal tensions have taken place in the state since Samajwadi Party came to power in March this year.

This has given opportunity to BJP to take on Samajwadi Party government in the state. While on the one hand, BJP leaders are now lambasting Akhilesh-led SP government for adopting Muslim appeasement policy, on the other hand they have questioned the state government's inability to contain communal tensions especially in Faizabad, Bareilly, Mathura, Ghaziabad etc.

The BJP has now decided to hold a Hahakar Rally on December 15 at Meerut on law and order issue and even presented reports of their fact-finding team on clashes in Mathura, Banda, and Sultanpur on Wednesday itself. The BJP state chief Laxmikant Bajpayi also demanded to the chief minister to set up a probe into a dozen communal clashes that have taken place in the last over five months by special investigation agency.A planned revival of Hindutva, it seems!

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Flu season strikes early and, in some places, hard


NEW YORK (AP) — From the Rocky Mountains to New England, hospitals are swamped with people with flu symptoms. Some medical centers are turning away visitors or making them wear face masks, and one Pennsylvania hospital set up a tent outside its ER to deal with the feverish patients.


Flu season in the U.S. has struck early and, in many places, hard.


While flu normally doesn't blanket the country until late January or February, it is already widespread in more than 40 states, with about 30 of them reporting some major hot spots. On Thursday, health officials blamed the flu for the deaths of 20 children so far.


Whether this will be considered a bad season by the time it has run its course in the spring remains to be seen.


"Those of us with gray hair have seen worse," said Dr. William Schaffner, a flu expert at Vanderbilt University in Nashville.


The evidence so far points to a moderate season, Schaffner and others say. It looks bad in part because last year was unusually mild and because the main strain of influenza circulating this year tends to make people sicker and really lay them low.


David Smythe of New York City saw it happen to his 50-year-old girlfriend, who has been knocked out for about two weeks. "She's been in bed. She can't even get up," he said.


Also, the flu's early arrival coincided with spikes in a variety of other viruses, including a childhood malady that mimics flu and a new norovirus that causes vomiting and diarrhea, or what is commonly known as "stomach flu." So what people are calling the flu may, in fact, be something else.


"There may be more of an overlap than we normally see," said Dr. Joseph Bresee, who tracks the flu for the Centers for Disease Control and Prevention.


Most people don't undergo lab tests to confirm flu, and the symptoms are so similar that it can be hard to distinguish flu from other viruses, or even a cold. Over the holidays, 250 people were sickened at a Mormon missionary training center in Utah, but the culprit turned out to be a norovirus, not the flu.


Flu is a major contributor, though, to what's going on.


"I'd say 75 percent," said Dr. Dan Surdam, head of the emergency department at Cheyenne Regional Medical Center, Wyoming's largest hospital. The 17-bed emergency room saw its busiest day ever last week, with 166 visitors.


The early onslaught has resulted in a spike in hospitalizations. To deal with the influx and protect other patients from getting sick, hospitals are restricting visits from children, requiring family members to wear masks and banning anyone with flu symptoms from maternity wards.


One hospital in Allentown, Pa., set up a tent this week for a steady stream of patients with flu symptoms. But so far "what we're seeing is a typical flu season," said Terry Burger, director of infection control and prevention for the hospital, Lehigh Valley Hospital-Cedar Crest.


On Wednesday, Boston declared a public health emergency, with the city's hospitals counting about 1,500 emergency room visits since December by people with flu-like symptoms.


All the flu activity has led some to question whether this year's flu shot is working. While health officials are still analyzing the vaccine, early indications are that it's about 60 percent effective, which is in line with what's been seen in other years.


The vaccine is reformulated each year, based on experts' best guess of which strains of the virus will predominate. This year's vaccine is well-matched to what's going around. The government estimates that between a third and half of Americans have gotten the vaccine.


In New York City, 57-year-old Judith Quinones skipped getting a flu shot this season and suffered her worst case of flu-like illness in years. She was laid up for nearly a month with fever and body aches. "I just couldn't function," she said.


But her daughter got the vaccine. "And she got sick twice," Quinones said.


Europe is also suffering an early flu season, though a milder strain predominates there. Flu reports are up, too, in China, Japan, the West Bank, the Gaza Strip, Algeria and the Republic of Congo. Britain has seen a surge in cases of norovirus.


On average, about 24,000 Americans die each flu season, according to the CDC. That's an estimate — the agency does not keep a running tally of adult flu deaths each year, only for children. Some state health departments do keep count, and they've reported dozens of flu deaths so far.


Flu usually peaks in midwinter. Symptoms can include fever, cough, runny nose, head and body aches and fatigue. Some people also suffer vomiting and diarrhea, and some develop pneumonia or other severe complications.


Most people with flu have a mild illness and can help themselves and protect others by staying home and resting. But people with severe symptoms should see a doctor. They may be given antiviral drugs or other medications to ease symptoms.


Flu vaccinations are recommended for everyone 6 months or older. Of the 20 children killed by the flu this season, only two were fully vaccinated.


___


AP Medical Writer Maria Cheng in London contributed to this report.


___


Online:


CDC flu: http://www.cdc.gov/flu/index.htm


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Judge: Holmes Can Face Trial for Aurora Shooting


Jan 10, 2013 8:45pm







ap james holmes ll 120920 wblog Aurora Shooting Suspect James Holmes Can Face Trial

(Arapahoe County Sheriff/AP Photo)


In a ruling that comes as little surprise, the judge overseeing the Aurora, Colo., theater massacre has ordered that there is enough evidence against James Holmes to proceed to a trial.


In an order posted late Thursday, Judge William Sylvester wrote that “the People have carried their burden of proof and have established that there is probable cause to believe that Defendant committed the crimes charged.”


The ruling came after a three-day preliminary hearing this week that revealed new details about how Holmes allegedly planned for and carried out the movie theater shooting, including how investigators say he amassed an arsenal of guns and ammunition, how he booby-trapped his apartment to explode, and his bizarre behavior after his arrest.


PHOTOS: Colorado ‘Dark Knight Rises’ Theater Shooting


Holmes is charged with 166 counts, including murder, attempted murder and other charges related to the July 20 shooting that left 12 people dead and 58 wounded by gunfire. An additional 12 people suffered non-gunshot injuries.


One of the next legal steps is an arraignment, at which Holmes will enter a plea. The arraignment was originally expected to take place Friday morning.


Judge Sylvester indicated through a court spokesman that he would allow television and still cameras into the courtroom, providing the outside world the first images of Holmes since a July 23 hearing. Plans for cameras in court, however, were put on hold Thursday afternoon.


“The defense has notified the district attorney that it is not prepared to proceed to arraignment in this case by Friday,” wrote public defenders Daniel King, Tamara Brady and Kristen Nelson Thursday afternoon in a document objecting to cameras in court.


A hearing in the case will still take place Friday morning. In his order, Judge Sylvester said it should technically be considered an arraignment, but noted the defense has requested a continuance.  Legal experts expect the judge will grant the continuance, delaying the arraignment and keeping cameras out of court for now.


Sylvester also ordered that Holmes be held without bail.


Holmes’ attorneys have said in court that the former University of Colorado neuroscience student is mentally ill. The district attorney overseeing the case has not yet announced whether Holmes, now 25, can face the death penalty.



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Analysis: Modi's Gujarat growth model might not work across India


SURAT, India (Reuters) - Turning a single Indian state with a long tradition of entrepreneurship and a solid political majority into an investor-friendly economic powerhouse is one thing.


Replicating that experience across a diverse country of 1.2 billion would be a tougher prospect for Narendra Modi, whose leadership of booming Gujarat state has led to his being touted as a potential candidate to become India's next prime minister.


While Modi wins praise even from critics for cutting red tape and making government more responsive and predictable, many ingredients for Gujarat's run of growth were in place well before he took office in 2001.


"It is like an icing on cake sort of thing. You have a nice cake and Modi has done a lot of good icing," said Rakesh Chaudhary, director of Pratibha Group, a textile manufacturer in Palsana on the outskirts of the Gujarat city of Surat.


Industry in Gujarat is helped by a long coastline and plenty of barren land that is easy to turn over to factory use.


The power that comes from a long-standing and heavy majority for his Bharatiya Janata Party (BJP) in the state also gives Modi an advantage that he would not enjoy on a national stage marked by fractious coalition politics.


Despite a controversial past - Modi is accused by critics of not doing enough to stop or of even quietly encouraging religious riots in 2002 that saw as many as 2,000 killed, most of them Muslims - he has established a reputation as an economic reformer in part by building on the strengths of Gujarat and marketing them heavily.


Modi's marketing savvy, aided by the Washington lobbying and public affairs firm APCO Worldwide, will be on display at the biennial "Vibrant Gujarat Summit" that begins on Friday.


Initiated by Modi in 2003 to attract investment after the violence and an earthquake in 2001, the event is attended by thousands of corporate officials who pledge billions in investment, although in reality only a fraction has seen the light of day. Of 12.4 trillion rupees ($225 billion) in investment proposed at the 2009 event, just 8.5 percent had been spent as of November 2011, according to state government data.


"Under Modi's regime, there has been significant improvement in infrastructure growth, significant improvement in industrialization, as well as agriculture," said Jahangir Aziz, senior Asia economist at JPMorgan. "But what has been overplayed is initial conditions were actually pretty decent in Gujarat."


HIGHER OFFICE?


The stocky Modi, who favors traditional Indian attire and a clipped white beard, plays down any prime ministerial ambitions.


But his popularity in Gujarat - the BJP won 115 of the state assembly's 182 seats in a December election - has fuelled speculation that he could lead his Hindu nationalist party in 2014 against India's ruling Congress party, which has been beset by corruption scandals and overseen a sharp economic slowdown.


"His economic record in Gujarat is obviously something which matters a lot to the middle classes. That, coupled with strong leadership," said Swapan Dasgupta, an analyst with links to the BJP who expects Modi to be the party standard-bearer in 2014.


Critics say that while Modi has indeed encouraged investment and helped bring reliable electricity and law and order, double-digit growth has not been shared broadly enough. In the five years through March 2010, some states - including Tamil Nadu and Karnataka - did better at bringing down poverty levels.


"Big business people get a lot from the government and scheduled caste people (minorities) get a lot, but people like us who are in between get nothing," said Bhupendra Thakkar, 50, who earns 6,000 rupees ($109) a month selling fruit near Surat's decrepit railway station.


FRIEND OF BUSINESS


Modi lured Tata Motors to the state in 2008 after the company's plans to build a factory for its low-cost Nano car were thwarted by farmers in West Bengal.


Ford Motor Co and Maruti Suzuki are also building plants in the western state - high profile investments that carry the added benefit of acting as marketing tools.


In the seven years through March 2011, Gujarat's economy grew an annual 10.08 percent at constant prices, against 6.45 percent in the eight years through March 2002 (Modi took office in October 2001), which was still ahead of the all-India average of 6.16 percent. A handful of states, including Maharashtra and Tamil Nadu, clocked bigger gains over the same recent period.


By comparison, policy gridlock at the national level has contributed to a drop-off in corporate investment, putting India on track to record its slowest annual growth rate in a decade.


Accustomed to getting his way, Modi, 62, could struggle to negotiate the coalition politics that have become the norm at the national level and have hindered attempts at reform by Prime Minister Manmohan Singh's Congress-led administration.


"Policymaking has benefited from the fact that the BJP has had absolute majority in the state legislature - an advantage it certainly will not enjoy in the federal parliament," said Anjalika Bardalai, an analyst with the Eurasia Group in London.


Modi has also been able to leverage the business acumen of Gujaratis, a group that has long been known for trading and entrepreneurship and includes a prosperous global diaspora as well as billionaires such as Adani Group chief Gautam Adani and Mukesh Ambani, who controls Reliance Industries, India's most valuable company.


"Modi might not be as successful as he has been here because the business mentality is unique to Gujarat," said Chandrakant Sanghavi, chairman of Sanghavi Exports International, a diamond trader and processor. "It could be prevalent in other states but the ratio may be less." ($1 = 55.0700 Indian rupees)


(Editing by John Chalmers and Alex Richardson)



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'Twilight' finale tops anti-Oscar Razzies shortlist






LOS ANGELES: The last installment of the blockbuster "Twilight" franchise has won the dubious honor of being nominated in every category for Hollywood's anti-Oscar Razzie awards.

"Twilight: Breaking Dawn - Part 2" topped the shortlist of the Golden Raspberries, handed out each year as an alternative to Tinseltown's annual back-slapping awards season, which moves into top gear this week.

Others tipped for Razzie shame include veteran diva Barbra Streisand for worst actress in mother-son road movie "The Guilt Trip," while Nicolas Cage, Eddie Murphy and Adam Sandler are all up for worst actor.

"Twilight" stars Robert Pattinson and Kristen Stewart are nominated for worst actor and actress, while the film's director Bill Condon was tipped for worst filmmaker, in shortlists for all 10 Razzie categories unveiled Tuesday.

The tongue-in-cheek dishonor award will not matter much to the makers of the "Twilight" films -- the fifth and final installment of the wildly-popular franchise has taken nearly $800 million at the box office worldwide, according to the IMDb movie industry website.

The other films shortlisted for worst movie of 2012 were "Battleship," family movie "The Oogieloves in the Big Balloon Adventure," Adam Sandler comedy "That's My Boy" and "A Thousand Words" starring comedy veteran Murphy.

The Razzie winners will be announced on February 23, the day before the Academy Awards. Nominations for the Oscars are due to be announced early Thursday in Beverly Hills.

Here are the full shortlists in the main Razzie categories:

Worst director: Sean Anders, "That's My Boy"; Peter Berg, "Battleship"; Bill Condon, "The Twilight Saga: Breaking Dawn Part 2"; Tyler Perry, "Good Deeds"/"Madea's Witness Protection"; and John Putch, "Atlas Shrugged II."

Worst Actress: Katherine Heigl, "One for the Money"; Milla Jovovich, "Resident Evil: Retribution"; Tyler Perry, "Madea's Witness Protection"; Kristen Stewart, "The Twilight Saga"/"Snow White and the Huntsman."

Worst Actor: Nicolas Cage, "Ghost Rider 2: Spirit of Vengeance"/"Seeking Justice"; Eddie Murphy, "A Thousand Words"; Robert Pattinson, "The Twilight Saga"; Tyler Perry, "Alex Cross"/"Good Deeds"; Adam Sandler, "That's My Boy."

Worst Supporting Actress: Jessica Biel, "Playing For Keeps"/"Total Recall"; Brooklyn Decker, "Battleship"/"What to Expect When You're Expecting"; Ashley Greene, "The Twilight Saga"; Jennifer Lopez, "What to Expect When You're Expecting"; Rihanna, "Battleship."

Worst Supporting Actor: David Hasselhoff, "Piranha 3-DD"; Taylor Lautner, "The Twilight Saga"; Liam Neeson, "Battleship"/"Wrath of the Titans"; Nick Swardson, "That's My Boy"; Vanilla Ice, "That's My Boy."

- AFP/ck



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Kin bid tearful adieu to soldier killed by Pakistan troops

MATHURA: Hundreds of villagers joined family in bidding adieu on late Wednesday evening to deceased Lance Naik Hemraj Singh, who was killed by Pakistan troops during a ceasefire violation in Jammu and Kashmir.

In Singh's native village of Shernagar under Mathura district of Uttar Pradesh, scores of locals flocked to the soldier's residence to honour him.

The inconsolable family of the soldier comprising an ageing mother, his wife, two daughters and a toddler son was seen being pacified by local women.

Army officials who escorted Singh's coffin from New Delhi participated in the last rite and also gave a rifle salute by firing several rounds in the air in honour of the soldier who died at the hands of the enemy at the Line of Control (LoC).

Lance Naik Hemraj, one of the two Indian soldiers killed by Pakistani troops in a violation of truce on the Kashmir border, was the family's sole breadwinner.

Hemraj, who joined the Army in 2001, was the second of three brothers and the sole earning member of his family after the death of his father.

Pakistani troops crossed the territory's heavily militarised LoC on Tuesday (January 08) and fired at an Indian army patrol.

The body of one of the soldiers was found "badly mutilated" in a forested area on the side controlled by India, Indian military officials said. Pakistan has denied the allegation.

The army had said that in a separate incident later on Tuesday, both sides shot at each other for more than an hour across the Line of Control (LoC) that divides Jammu and Kashmir.

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Retooling Pap test to spot more kinds of cancer


WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.


Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.


How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.


In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.


This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.


"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.


But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.


The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.


"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.


"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.


But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.


More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.


Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.


The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.


So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.


The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.


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Holmes 'Delighted' by Creepy Self-Portraits: Victims













After two days of apparent indifference, accused Aurora shooter James Holmessmiled and smirked at disturbing self-portraits and images of weapons shown in court today, according to the families of victims who watched him.


"When he sees himself, he gets very excited and his eyes crinkle," Caren Teves said outside of the courthouse, after the hearing. "Your eyes are the window to the soul and you could see that he was very delighted in seeing himself in that manner."


Teves' son Alex Teves, 24, died in the shooting.


Prosecutors showed photos that Holmes took of himself hours before he allegedly carried out a massacre at a Colorado movie theater. He took a series of menacing self-portraits with his dyed orange hair curling out of from under a black skull cap and his eyes covered with black contacts. In some of the photos, guns were visible.


Those haunting photographs, found on his iPhone, were shown in court today on the last day of a preliminary testimony that will lead to a decision on whether the case will go to trial. The hearing concluded without Holmes' defense calling any witnesses.


The judge's decision on whether the case will proceed to trial is expected on Friday.








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Couple Surprised by Rebuilt Home After Sandy Watch Video





Holmes, 25, is accused of opening fire on a crowded movie theater in Aurora, Colo., on July 20, 2012, killing 12 people and wounding dozens others during a showing of "Dark Knight Rises."


The court room's set-up kept members of the media from being able to see Holmes' face as the photos were displayed, but victims and their families could watch him.


Teves said that Holmes was "absolutely smirking" when images of his weapons and the iPhone photos he took of himself were shown in court.


"I watched him intently," Caren Teves' husband Tom Teves said. "I watched him smile every time a weapon was discussed, every time they talked about his apartment and how he had it set up (with booby traps), and he could have gave a darn about the people, to be quite frank. But he's not crazy one bit. He's very, very cold. He's very, very calculated."


Holmes' has exhibited bizarre behavior after the shooting and while in custody. His defense team has said that he is mentally ill, but have not said if he will plead insanity.


"He has a brain set that no one here can understand and we want to call him crazy because we want to make that feel better in our society, but we have to accept the fact that there are evil people in our society that enjoy killing any type of living thing," a frustrated Tom Teves said. "That doesn't make them crazy. And don't pretend he's crazy. He's not crazy."


The photos presented in court showed Holmes mugging for his iPhone camera just hours before the shooting.


Click here for full coverage of the Aurora movie theater shooting.


Half-a-dozen photos showed Holmes with his clownish red-orange hair and black contact lenses giving the photos a particularly disturbing edge.


In one particularly odd image, he was making a scowling face with his tongue out. He was whistling in another photo. Holmes is smiling in his black contacts and flaming hair in yet another with the muzzle of one of his Glock pistols in the forefront.


Yet another photo showed him dressed in black tactical gear, posing with an AR-15 rifle.






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